Seth Meyers' Golden Globes opening.

Seth’s brutal Golden Globes joke

SETH Meyers has skewered the wave of sexual misconduct in Hollywood in a biting opening monologue at the 2017 Golden Globe Awards in Los Angeles - and he saved a particularly brutal joke for Harvey Weinstein.

"Good evening ladies and remaining gentlemen," the comedian said, opening the show as the audience of A-listers cheered.

"Happy New Year Hollywood. It's 2018 - marijuana is finally allowed, sexual harassment finally isn't ... its gonna be a good year."

As allegations of sexual misconduct mounted and came to light in recent months, many wondered how Meyers would tackle the news that has dominated the headlines. Tasked with hosting the first big ceremony since claims about heavyweights like Harvey Weinstein and Kevin Spacey surfaced, Meyers himself joked he felt like "the first dog they shot into outer space". And almost all of the 15 minute monologue was devoted to taking jabs at the issue.

"There's a new era underway and I can tell because it has been years since a white man has been this nervous in Hollywood," he said.

"For the male nominees in the room this is the first time in three months it won't be terrifying to hear your name read out."

In a joke directed at Harvey Weinstein, Meyers referred to the disgraced movie mogul as the "elephant not in the room".

"Harvey Weinstein isn't here tonight ... I've heard rumours he's crazy and difficult to work with," he said.

"He'll be back in 20 years when he's the first person booed in the in memoriam," Meyers added, as the audience gasped in shock.

In the first award of the night, Nicole Kidman picked up the gong for her role in Big Little Lies.

She took the stage with a message to her female co-stars: "This is ours to share. Wow, the power of women."

She ended the speech by addressing her husband in the audience directly.

"Keith Urban, when my cheek is against yours, everything melts away, and that is love. It's true - I love you so much."

Sam Rockwell took home the award for Best Performance by an Actor in a Supporting Role in any Motion Picture for his role in Three Billboards Outside Ebbing, Missouri.

Jennifer Aniston and TV icon Carol Burnett presented the award for Best Actress in a TV series, Musical or Comedy - Aniston gushing over Burnett, and Burnett responding with a well-timed quip: "I'm glad you're coming back to television… I loved Will & Grace."

Rachel Brosnahan took home the gong for The Marvellous Mrs Maisel.

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